Kai-Chun Yang個人資料

Human Brain Research Center at Taichung Veterans General Hospital, Taiwan

臺中榮民總醫院臨床腦科學研究中心

Kai-Chun Yang, M.D., Ph.D.
Department of Psychiatry, Taipei Veterans General Hospital, Taiwan

Office 

Department of Psychiatry,Taipei Veterans General Hospital Taipei, Taiwan

Office address: Department of Psychiatry, Taipei Veterans General Hospital, 11217 Taipei, Taiwan.

Telephone Office: +886-2-28757027

Email: kcyang2@gmail.com

Education

  1996-2003         M.D.         National Yang-Ming University, Taipei, Taiwan 

  2013-2017         Ph.D.        Karolinska Institutet, Stockholm, Sweden 

Appointments

2002–2003

Intern, Taichung Veterans General Hospital, Taichung, Taiwan

2003-2005

Compulsory Military Service, Air Force 499th Tactical Fighter Wing, Second Lieutenant and Internist

2005–2008

Resident, Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan

2008-2009

Chief Resident, Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan

2009-2013

Attending Psychiatrist, Department of Psychiatry, Taipei Veterans General Hospital Yuanshan Branch, Yilan, Taiwan. 

2017-present

Attending Psychiatrist, Department of Psychiatry, Taipei Veterans General Hospital Taipei, Taiwan

2019-2023

Assistant Professor, Psychiatric Division, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan

2023-present

Associate Professor, Psychiatric Division, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan

2024-present

Chief, Section of Psychosomatic Medicine, Department of Psychiatry, Taipei Veterans General Hospital Taipei, Taiwan

Board Certification

        2008                             Taiwanese Society of Psychiatry

        2020                             Taiwanese Society of Addiction Science

Professional Honors

        2011                              Fellowship Award, 2nd AsCNP (Asian College of Neuropsychopharmacology), Seoul, Korea

Publication

  1. KC Yang, YJ Chou, BH Yang, CC Lan, SW Yang, YT Jou, YH Chou. Impact of clinical factors on reproducibility of dopamine transporter imaging: A 99mTc-TRODAT SPECT study with sufficient size. Progress in Neuro-Psychopharmacology and Biological Psychiatry 2025; 38: 11370. DOI: 10.1016/j.pnpbp.2025.111370
  2. KC Yang, BH Yang, CC Lan, MN Liu, YH Chou. Striatal and peripheral dopaminergic alterations related to cognitive impairment in patients with schizophrenia. Psychological Medicine 2024; 54(15): 4182-4192. DOI: 10.1017/S0033291724002228
  3.  KC Yang, BH Yang, MN Liu, YJ Liou, YH Chou. Cognitive impairment in schizophrenia is associated with prefrontal–striatal functional hypoconnectivity and striatal dopaminergic abnormalities. Journal of Psychopharmacology 2024; 38(6):515-525. DOI: 10.1177/02698811241257877
  4. YJ Liou, MN Liu, KC Yang, LY Hu, WC Hsieh, YH Chou. Hippocampal subfields in remitted schizophrenia. Journal of the Chinese Medical Association 2024; 87 (6), 627-634. DOI: 10.1097/jcma.0000000000001100
  5. MN Liu, LY Hu, CF Tsai, CJ Hong, YH Chou, CC Chang, KC Yang, ZH You, CI Lau. Abnormalities of Hippocampal Subfield and Amygdalar Nuclei Volumes and Clinical Correlates in Behavioral Variant Frontotemporal Dementia with Obsessive–Compulsive Behavior-A Pilot Study. Brain Sciences 2023; 13 (11): 1582. DOI: 10.3390/brainsci13111582
  6. CW Chen, YH Chou, YJ Liou, KC Yang, LY Hu, WC Hsieh, MN Liu. Amygdala substructure volumes and serotonin transporter in first-episode, drug-naïve major depressive disorder: A pilot study. Journal of Psychiatric Research 2023; 160: 210-216. DOI: 10.1016/j.jpsychires.2023.02.015
  7. KC Yang, YY Chen, MN Liu, BH Yang, YH Chou. Interactions between dopamine transporter and N-methyl-d-aspartate receptor-related amino acids on cognitive impairments in schizophrenia. Schizophrenia Research 2022; 248: 263-270. DOI: 10.1016/J.SCHRES.2022.09.022
  8. KC Yang, WC Hsieh, YH Chou. Cognitive factor structure and measurement invariance between healthy controls and patients with major depressive disorder. Journal of Psychiatric Research 2022; 151: 598-605. DOI: 10.1016/j.jpsychires.2022.05.029
  9. KC Yang, MN Liu, BH Yang, YH Chou. Role of dopamine transporter in the relationship between plasma cortisol and cognition. Psychosomatic Medicine 2022; 84(6): 685–694. DOI: 10.1097/psy.0000000000001089
  10. MN Liu, JG Pantouw, KC Yang, LY Hu, YJ Liou, JF Lirng, YH Chou. Sub-regional hippocampal volumes in first-episode drug-naïve major depression disorder. Neuroscience Letters 2021; 763: 136178. DOI: 10.1016/j.neulet.2021.136178
  11. KC Yang, YT Liao, YK Yang, SK Lin, CS Liang, YM Bai. Evidence-Based Expert Consensus Regarding Long-Acting Injectable Antipsychotics for Schizophrenia from the Taiwanese Society of Biological Psychiatry and Neuropsychopharmacology (TSBPN). CNS Drugs 2021; 35(8): 893–905 (#contributed equally). DOI: 10.1007/s40263-021-00838-5
  12. YC Chiu, BH Yang, KC Yang, MN Liu, LY Hu, YJ Liou, LY Chan, YH Chou. A study of tryptophan, kynurenine and serotonin transporter in first-episode drug-naïve major depressive disorder. Psychiatry Research: Neuroimaging 2021; 312: 111296. DOI: 10.1016/j.pscychresns.2021.111296
  13. KC Yang, MN Liu, YJ Liou, LY Hu, BH Yang, YH Chou. Interleukin-1 family and serotonin transporter in first-episode, drug-naive major depressive disorder: a pilot study. Journal of Psychiatric Research 2021; 135: 174–180. DOI: 10.1016/j.jpsychires.2021.01.018
  14. KC Yang, BH Yang, JF Lirng, MN Liu, LY Hu, YJ Liu, LA Chen, YH Chou. Interaction of dopamine transporter and metabolite ratios underpinning the cognitive dysfunction in patients with carbon monoxide poisoning: A combined SPECT and MRS study. Neurotoxicology 2021; 82: 26–34. DOI: 10.1016/j.neuro.2020.11.002
  15. KC Yang, V Stepanov, N Amini, S Martinsson, A Takano, C Bundgaard, B Bang-Andersen, C Sanchez, C Halldin, L Farde, SJ Finnema. Effect of clinically relevant doses of vortioxetine and citalopram on serotonergic PET markers in the nonhuman primate brain. Neuropsychopharmacology 2019; 44(10): 1706–1713. DOI: 10.1038/s41386-019-0442-4
  16. CT Li, KC Yang, WC Lin. Glutamatergic Dysfunction and Glutamatergic Compounds for Major Psychiatric Disorders: Evidence From Clinical Neuroimaging Studies. Frontiers in Psychiatry 2019; 9: 767. DOI: 10.3389/fpsyt.2018.00767
  17. KC Yang, A Takano, C Halldin, L Farde, SJ Finnema. Serotonin concentration enhancers at clinically relevant doses reduce [11C]AZ10419369 binding to the 5-HT1B receptors in the nonhuman primate brain. Translational Psychiatry 2018; 8: 132. DOI: 10.1038/s41398-018-0178-7
  18. R Arakawa, L Farde, J Matsumoto, N Kanegawa, I Yakushev, KC Yang, A Takano. Potential Effect of Prolonged Sevoflurane Anesthesia on the Kinetics of [11C]Raclopride in Non-human Primates. Molecular Imaging and Biology 2018; 20(2):183–187. DOI: 10.1007/s11307-017-1120-8
  19. KC Yang, V Stepanov, S Martinsson, A Ettrup,A Takano, GM Knudsen, C Halldin, L Farde, SJ Finnema. Fenfluramine Reduces [11C]Cimbi-36 Binding to the 5-HT2A Receptor in the Nonhuman Primate Brain. International Journal of Neuropsychopharmacology 2017; 20(9):683–691. DOI: 10.1093/ijnp/pyx051
  20. KC Yang, V Stepanov, N Amini, S Martinsson, A Takano, J Nielsen, C Bundgaard, BB Andersen, S Grimwood, C Halldin, L Farde, SJ Finnema. Characterization of [11C] Lu AE92686 as a PET radioligand for phosphodiesterase 10A in the nonhuman primate brain. European Journal of Nuclear Medicine and Molecular Imaging 2017; 44 (2), 308–320. DOI: 10.1007/s00259-016-3544-9
  21. KC Yang, SJ Wang, WC Hsieh, JF Lirng, CC Yang, JF Deng, CL Lin, YH Chou. Longitudinal changes in the dopamine transporter and cognition in suicide attempters with charcoal burning. Psychiatry Research: Neuroimaging 2015; 231 (2), 160–167. DOI: 10.1016/j.pscychresns.2014.12.002
  22. JW Hsu, JF Lirng, SJ Wang, CL Lin, KC Yang, MH Liao, YH Chou. Association of thalamic serotonin transporter and interleukin‐10 in bipolar I disorder: a SPECT study. Bipolar Disorders 2014; 16 (3), 241–248. DOI: 10.1111/bdi.12164
  23. YH Chou, CK Chen, SJ Wang, SJ Tsai, JF Lirng, YJ Liou, CL Lin, KC Yang, MW Lin, WC Lo, MH Liao, CC Chen. Association of Brain Serotonin Transporter Availability and Brain-Derived Neurotrophic Factor in Models of Serotonin Transporter Genotypes in Healthy Subjects. Journal of Clinical Psychopharmacology 2013; 33(3), 432–435. DOI: 10.1097/jcp.0b013e3182904a80
  24. YH Chou, CL Lin, SJ Wang, JF Lirng, KC Yang, AC Chang, MH Liao. Aggression in bipolar II disorder and its relation to the serotonin transporter. Journal of Affective Disorders 2013; 147 (1–3), 59–63. DOI: 10.1016/j.jad.2012.10.007
  25. YH Chou, SJ Wang, JF Lirng, CL Lin, KC Yang, CK Chen, CB Yeh, MH Liao. Impaired cognition in bipolar I disorder: The roles of the serotonin transporter and brain-derived neurotrophic factor. Journal of Affective Disorders 2012; 143 (1–3), 131–137. DOI: 10.1016/j.jad.2012.05.043
  26. KC Yang, HL Ku, CL Wu, SJ Wang, CC Yang, JF Deng, MB Lee, YH Chou. Striatal dopamine transporter binding for predicting the development of delayed neuropsychological sequelae in suicide attempters by carbon monoxide poisoning: A SPECT study. Psychiatry Research: Neuroimaging 2011; 194 (3), 219–223. DOI: 10.1016/j.pscychresns.2011.04.006
  27. CL Wu, KC Yang, SJ Wang, YH Chou. Aripiprazole can treat psychotic features but not motor symptoms of Parkinson’s disease: Evidence from a SPECT study. Progress in Neuro-psychopharmacology & Biological Psychiatry 2011; 35 (1), 278–279. DOI: 10.1016/j.pnpbp.2010.09.009
  28. YH Chou, WS Huang, JW Hsu, SM Lee, AS Yang, KC Yang. Simultaneous Measurement of Dopamine Transporters and D2/D3 Receptors in Drug Naive Schizophrenic Patients. Clinical Psychopharmacology and Neuroscience 2010; 8 (2), 97–104.
  29. HL Ku, KC Yang, YC Lee, MB Lee, YH Chou. Predictors of carbon monoxide poisoning-induced delayed neuropsychological sequelae. General hospital psychiatry 2010; 32 (3), 310–314. DOI: 10.1016/j.genhosppsych.2009.11.005
  30. CT Li, YH Chou, KC Yang, CH Yang, YC Lee, TP Su. Medically unexplained symptoms and somatoform disorders: diagnostic challenges to psychiatrists. Journal of the Chinese Medical Association 2009; 72 (5), 251–256. DOI: 10.1016/s1726-4901(09)70065-6
  31. YM Bai, KH Chou, CP Lin, IY Chen, CT Li, KC Yang, YH Chou, TP Su. White matter abnormalities in schizophrenia patients with tardive dyskinesia: a diffusion tensor image study. Schizophrenia research 2009; 109 (1-3), 167–181. DOI: 10.1016/j.schres.2009.02.003
  32. KC Yang, TP Su, YH Chou. Effectiveness of aripiprazole in treating obsessive compulsive symptoms. Progress in Neuro-psychopharmacology & Biological Psychiatry 2008; 32 (2), 585–586. DOI: 10.1016/j.pnpbp.2007.10.009 
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